All of Us is shaping how we understand health and disease. Research Highlights showcase the recent research powered by All of Us data and tools.
Featured Highlight
All of Us and Artificial Intelligence Help Speed Up the Search for Promising Medicines
Artificial intelligence and All of Us may help speed up the time it takes to find medicines to treat health conditions. Researchers used ChatGPT to quickly identify existing medicines that might help prevent Alzheimer’s disease. They then looked at All of Us and another large health dataset to confirm that three of these medicines are worth studying in people.
What All of Us Shows About Cholesterol and Breast Cancer Risk
Researchers looked at All of Us data to better understand whether cholesterol affects breast cancer risk. High levels of some cholesterol measures were linked to an increased risk of breast cancer. But for other measures, it is not so simple.
Rare Finding in All of Us Data Affects DNA Testing for Certain Cancer Drugs
Experts thought that two variants in the DPYD gene always occurred together. A recent study of DNA data from more than 245,000 All of Us participants found that the variants do not always occur together. This finding has changed how health care providers use DNA tests to decide on the right dose of certain cancer treatments.
All of Us Data Shows That Many People With Diabetes Are Undertreated
Researchers looked at All of Us data to study whether people with diabetes are getting statins and other medicines to reduce their risk of heart disease and stroke. About half of the participants were not. Thanks to All of Us participants, we now know more about the need for better management of heart disease risk in people with diabetes.
All of Us Helps Link Health Conditions With Severe COVID-19 Risk
A study linked 27 health conditions, including obesity, substance use disorders, and breathing problems, to the risk of severe COVID-19 in people of European ancestry. This study involved data from DNA and health records from more than half a million participants from three databases, including All of Us.
Exploring Polygenic Risk Scores Using All of Us
Polygenic risk scores are a measure of how likely you are to get a particular health condition—your risk—based on changes in many genes in your DNA. However, these scores are often most accurate for people of European ancestry, because past research left out many other groups. Researchers adjusted polygenic risk scores for 10 common conditions using the diverse genetic data in All of Us so that the scores are accurate for people from a variety of backgrounds.